Bupropion was first developed to treat depression. It was later found
that it helped smokers to stop smoking and has become known as the
"stop smoking pill".
Bupropion is also sometimes prescribed for the treatment of bipolar
depression, attention deficit disorder and for the prevention of seasonal
affective disorder. It has also been indicated for other uses as follows:
Treatment of Sexual dysfunction
Although it is not an FDA-approved indication, a large body of evidence
exists in favor of Bupropion's use for the treatment of sexual dysfunction.
According to a survey, Bupropion is the drug of choice among psychiatrists
for the treatment of serotonin reuptake inhibitor (SSRI) induced
sexual dysfunction. In that survey, 36 percent of the responding
psychiatrists said they preferred switching their patients with
sexual dysfunction to Buproprion. There are studies demonstrating
its efficacy in the improvement of the desire and orgasm components
of the sexual function. Several studies have also indicated that
Bupropion helps to relieve sexual dysfunction among non-depressed
patients. Notably, Bupropion has also showed promise as a treatment
for sexual dysfunction caused by chemotherapy for breast cancer
and for orgasmic dysfunction.
Interestingly, Bupropion does not affect any measures of sexual
functioning in healthy males.
A recent review/meta-analysis confirmed the efficacy of Bupropion
(400 mg/day) for the treatment of obesity. Over a 6-12 month period,
weight loss achievements by Bupropion patients was comparable to
those of patients who were using more established weight loss medications
such as Sibutramine, Orlistat and Diethylpropion.